EXPLORING THE FRONTIER OF BASAL GANGLIA RESEARCH

Martin Parent, PhD

Professor, Université Laval

Principal Investigator, Cervo Brain Research Centre

My research team investigates the anatomical and functional organization of the basal ganglia, a set of subcortical structures involved in motor behavior, in rodents, human and non-human primates. Our research projects aim at characterizing alterations of neuronal circuits that occur in Parkinson’s disease and Huntington’s chorea using animal models of neurodegenerative diseases and post-mortem human brain. We take advantage of a vast array of methodological approaches that include in vivo electrophysiological recordings followed by tracer injections and three-dimensional reconstructions of neurons, examination of synaptic contacts by electron microscopy, localization of neurotransmitters and analysis of post-mortem human brain tissue using optical and confocal microscopy.

Recently Published Research

Intraoperative fiber optic guidance during chronic electrode implantation in deep brain stimulation neurosurgery: proof of concept in primates.

Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology.

High Sensitivity Mapping of Cortical Dopamine D2 Receptor Expressing Neurons.

Microglial Implication in Parkinson’s Disease: Loss of Beneficial Physiological Roles or Gain of Inflammatory Functions?

Intact primate brain tissue identification using a completely fibered coherent Raman spectroscopy system.

Funding Partners